Do not administer live vaccines to a ustekinumab recipient. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune system. Tofacitinib: (Major) Do not administer live virus vaccines to patients taking tofacitinib, as no data are available on the secondary transmission of infection by live vaccines. BCG vaccine is contraindicated in patients with a hypersensitivity to any component of the vaccine including monosodium glutamate hypersensitivity and polysorbate 80 hypersensitivity; the vaccine is also contraindicated in patients with an anaphylactic or other allergic reaction to a previous dose of BCG vaccine. Alkylating agents: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient. At least 6 weeks before initiation of alemtuzumab therapy, consider completion of all age appropriate vaccinations per current immunization guidelines. The immune response of the immunocompromised patient to vaccines may be decreased and adjusted doses or boosters that are more frequent may be required. If immunization is necessary, choose an alternative to live vaccination, or, consider a delay or change in the immunization schedule. The presence or size of a postvaccination tuberculin skin-test reaction does not predict whether vaccination will provide any protection against tuberculosis. Before vaccination, consider the variable protective efficacy of the vaccine, especially in adults; the difficulty of interpreting tuberculin skin test results after vaccination; the possible exposure risk of immunocompromised persons; and possible failure to implement known infection-control measures. Tacrolimus: (Severe) Do not administer live vaccines to tacrolimus recipients; no data are available regarding the risk of secondary transmission of infection by live vaccines in patients receiving tacrolimus. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune system. Bacteria were susceptible to doxycycline. Imatinib: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient. Teriflunomide: (Major) Due to the lack of clinical information related to the safety and efficacy of vaccine administration during teriflunomide use, concomitant vaccination with live vaccines is not recommended. The CDC has stated that discontinuation of steroids for 1 month prior to live vaccine administration may be sufficient. No data are available on the response to live or inactive vaccines in patients receiving brodalumab therapy. At least 2 weeks before initiation of sirolimus therapy, consider completion of all age appropriate vaccinations per current immunization guidelines. Bacteria were susceptible to ciprofloxacin. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune system. The safety of immunization with live vaccines during or after emapalumab therapy has not been studied. Leflunomide: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient. Ofloxacin: (Major) Urinary concentrations of ofloxacin could interfere with the therapeutic effectiveness of BCG. Clofarabine: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient. Prednisolone: (Severe) Live vaccines should generally not be administered to an immunosuppressed patient. The responsible adult should report any adverse reaction following vaccine administration to the health care provider. The immune response of the immunocompromised patient to vaccines may be decreased, even despite alternate vaccination schedules or more frequent booster doses. Fluorouracil recipients may receive inactivated vaccines, but the immune response to vaccines or toxoids may be decreased. In adults, additional vaccine (1—2 drops) may be applied to assure a 'wet' vaccine site. Patients on corticosteroid treatment for 2 weeks or more may be vaccinated after steroid therapy has been discontinued for at least 3 months in accordance with general recommendations for the use of live vaccines. Clarithromycin: (Major) Urinary concentrations of clarithromycin could interfere with the therapeutic effectiveness of BCG. We do not record any personal information entered above. BCG Vaccination. The immunosuppressive effects of steroid treatment differ, but many clinicians consider a dose equivalent to either 2 mg/kg/day or 20 mg/day of prednisone as sufficiently immunosuppressive to raise concern about the safety of immunization with live vaccines. At least 2 weeks before initiation of blinatumomab therapy, consider completion of all age appropriate vaccinations per current immunization guidelines. Most children develop a sore at the injection site. Ocrelizumab: (Major) Due to the lack of clinical information related to the safety and efficacy of vaccine administration during ocrelizumab use, vaccination with live vaccines or live-attenuated vaccines is not recommended in patients taking ocrelizumab. Ethionamide: (Major) Urinary concentrations of ethionamide could interfere with the therapeutic effectiveness of BCG. Tuberculin skin testing should be performed prior to vaccination. Rituximab recipients may receive inactivated vaccines, but the immune response to vaccines or toxoids may be decreased. Lomustine, CCNU: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient. Before initiation of guselkumab therapy, consider completion of all age appropriate vaccinations per current immunization guidelines. Register Now. The bacterium used for the vaccine is called Mycobacterium bovis, which causes TB in animals such as cows and badgers.The bacteria in the vaccine are weakened (attenuated) so that they do not cause disease in healthy people. No data are available on the response to vaccinations or to the secondary transmission of infection by live vaccines in patients receiving certolizumab. Risankizumab: (Major) Avoid administration of live vaccines to risankizumab recipients. If immunization is necessary, choose an alternative to live vaccination, or, consider a delay or change in the immunization schedule. Prednisone: (Severe) Live vaccines should generally not be administered to an immunosuppressed patient. Live virus vaccines should generally not be administered to an immunosuppressed patient, as they may induce the illness they are intended to prevent. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. Amphotericin B-induced hypokalemia can result in interactions with other drugs. Percutaneous injection (BCG Vaccine, USP):Health care professionals should wear gloves, gown, and mask to avoid inadvertent exposure to BCG organisms while administering the vaccine.A separate multiple puncture device should be used for each person receiving the BCG vaccine. If immunization is necessary, choose an alternative to live vaccination, or, consider a delay or change in the immunization schedule. The manufacturer recommends deciding between discontinuing nursing or avoiding vaccination; however according to the Advisory Committee on Immunization Practices (ACIP), live virus vaccines do not affect the safety of breast-feeding. No data are available on the response to live or inactive vaccines in patients receiving tildrakizumab therapy. If immunization is necessary, choose an alternative to live vaccination, or, consider a delay or change in the immunization schedule. Patients on corticosteroid treatment for 2 weeks or more may be vaccinated after steroid therapy has been discontinued for at least 3 months in accordance with general recommendations for the use of live vaccines. Ifosfamide recipients may receive inactivated vaccines, but the immune response to vaccines or toxoids may be decreased. BCG, or bacille Calmette-Guerin, is a vaccine for tuberculosis (TB) disease. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune system. Muromonab-CD3: (Severe) Do not administer live vaccines to muromonab recipients; no data are available regarding the risk of secondary transmission of infection by live vaccines in patients receiving muromonab. Before initiation of obinutuzumab therapy, consider completion of all age appropriate vaccinations per current immunization guidelines. Because interleukin-1 blockade may interfere with immune response to infections, it is recommended that prior to initiation of therapy with canakinumab, adult and pediatric patients receive any recommended vaccination (including pneumococcal vaccine and inactivated influenza vaccines). Then, 0.2 to 0.3 mL of the diluted solution is dropped on the skin and administered using a multiple puncture disc. Depending on the adverse reaction, subsequent vaccination, if needed, may be contraindicated (see Contraindications)The health care professional should have immediate availability of epinephrine (1:1000) injection and other agents used in the treatment of anaphylaxis in the event of a serious allergic reaction.Inform the patient, parent, guardian, or responsible adult of the benefits and risks of the vaccine. Maximum dosage information is not available. The most controversial aspect of BCG is the variable efficacy found in different clinical trials, which appears to depend on geography. Mitoxantrone recipients may receive inactivated vaccines, but the immune response to vaccines or toxoids may be decreased. Nilotinib: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient. The Calmette-Guerin strain of M. bovis present in BCG vaccine is immunologically similar to M. tuberculosis. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. Vincristine recipients may receive inactivated vaccines, but the immune response to vaccines or toxoids may be decreased. Patients on corticosteroid treatment for 2 weeks or more may be vaccinated after steroid therapy has been discontinued for at least 3 months in accordance with general recommendations for the use of live vaccines. The immune response to an inactive vaccine may still be suboptimal. Data are limited regarding use of the Bacillus Calmette-Guerin (BCG) vaccine during breast-feeding and its' excretion in breast milk is unknown. Siltuximab: (Severe) Do not administer live vaccines to siltuximab recipients; no data are available regarding the risk of secondary transmission of infection by live vaccines in patients receiving siltuximab. Answer • Bacille Calmette-Guerin is a common cause of false positive tuberculosis tests. Although the TICE BCG product is obtained from a different strain (Tice strain), similar antimicrobial sensitivities may occur. At least 2 weeks before initiation of muromonab therapy, consider completion of all age appropriate vaccinations per current immunization guidelines. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune system. Hydroxocobalamin: (Major) Medications known to cause bone marrow suppression (e.g., myelosuppressive antineoplastic agents) may result in a blunted or impeded response to hydroxocobalamin, vitamin B12 therapy. Additional vaccine may be dropped on the skin after initial application to ensure a 'wet' vaccine site, and re-vaccination may be necessary. Amoxicillin; Clarithromycin; Omeprazole: (Major) Urinary concentrations of clarithromycin could interfere with the therapeutic effectiveness of BCG. Ce vaccin est destiné à lutter contre la tuberculose, sévère maladie respiratoire due au Bacille de Koch.Il n'est plus obligatoire pour les enfants depuis 2007. The BCG Vaccine is administered percutaneously with the multiple puncture disc for vaccination. No data are available on the secondary transmission of infection from persons receiving live vaccines to patients receiving tocilizumab. Siltuximab recipients may receive inactivated vaccines, but the immune response to vaccines or toxoids may be decreased. Before initiation of venetoclax therapy, consider completion of all age appropriate vaccinations per current immunization guidelines. No data are available regarding the risk of secondary transmission of infection by live vaccines, and the efficacy and safety of live vaccines have not been established in patients receiving fingolimod. Many people born outside of the United States have been given a vaccine called BCG. Drugs & Medications BCG Vaccine Injectable. Rifabutin: (Major) Urinary concentrations of rifabutin could interfere with the therapeutic effectiveness of BCG. Use of the BCG vaccine is contraindicated in patients who are immunosuppressed, as immunosuppression may lead to clinical disease (see Adverse Reactions) and prevent an appropriate immune response to BCG vaccination. No data are available on the secondary transmission of infection from persons receiving live vaccines. Amphotericin B-induced hypokalemia can result in interactions with other drugs. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune syste Ethambutol: (Major) Urinary concentrations of ethambutol could interfere with the therapeutic effectiveness of BCG. Dupilumab: (Major) Avoid administration of live vaccines to dupilumab recipients. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.. At least 4 weeks before initiation of rituximab therapy, consider completion of all age appropriate vaccinations per current immunization guidelines. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. Live virus vaccines should generally not be administered to an immunosuppressed patient. bTB a… Rituximab recipients may receive inactivated vaccines, but the immune response to vaccines or toxoids may be decreased. Streptozocin: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient. Fingolimod: (Severe) Do not administer live vaccines to a patient who is receiving fingolimod or has discontinued the drug in the last 2 months because of the risk of infection. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Satralizumab: (Major) Administer all live vaccines according to immunization guidelines at least 4 weeks before initiation of satralizumab. Tildrakizumab: (Major) Avoid administration of live vaccines to tildrakizumab recipients. If the skin is not punctured, repeat the procedure.Using the edge of the multiple puncture disc, re-spread the vaccine so that all puncture areas are filled. Rituximab; Hyaluronidase: (Severe) Do not administer live vaccines to rituximab recipients; no data are available regarding the risk of secondary transmission of infection by live vaccines in patients receiving rituximab. Dacarbazine, DTIC: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient. Postpone instillation of BCG if the patient is receiving antibiotics. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. The reporting of events is required by the National Childhood Vaccine Injury Act of 1986. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. Gentamicin: (Major) Urinary concentrations of gentamicin could interfere with the therapeutic effectiveness of BCG. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. 16-28 In a review of 10 randomized BCG trials, the average efficacy more than 10 years after vaccination was 14% (95% CI, –9% to 32%). If immunization is necessary, choose an alternative to live vaccination, or, consider a delay or change in the immunization schedule. Sensitivity of the Connaught strain to several antibiotics was tested in vitro. CAUTION: Bacillus Calmette-Guerin (BCG) Vaccine, USP, contains live bacteria and should be prepared in a biological safety cabinet and handled using aseptic technique. Natalizumab: (Severe) The immune response to vaccines or toxoids may be decreased in patients who receive natalizumab; however, no data are available. A century-old vaccine which was invented at the Pasteur Institutes in France, has generated interest among researchers in the fight against the new coronavirus. In contrast, 65 cases occurred among 1665 infants who were not vaccinated. Limited data are available on the response to live vaccination or on the risk of infection or infection transmission after the administration. Antithymocyte Globulin: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient. Amphotericin B-induced hypokalemia can result in interactions with other drugs. If immunization is necessary, choose an alternative to live vaccination, or, consider a delay or change in the immunization schedule. Amphotericin B: (Moderate) Administration of amphotericin B [lipid complex (ABLC), cholesteryl sulfate complex (ABCD), and liposomal (LAmB)] with antineoplastic agents may increase the potential for nephrotoxicity, bronchospasm, and hypotension. Live vaccines should not be given to individuals who are considered to be immunocompromised until more information is available. Patients with an active or a past mycobacterial infection (i.e., tuberculosis, TB) should not receive the BCG vaccine. The immune response of the immunocompromised patient to vaccines may be decreased, even despite alternate vaccination schedules or more frequent booster doses. Tacrolimus recipients may receive inactivated vaccines, but the immune response to vaccines or toxoids may be decreased. The immune response of the immunocompromised patient to vaccines may be decreased, even despite alternate vaccination schedules or more frequent booster doses. Inebilizumab: (Major) Administer all immunizations according to immunization guidelines at least 4 weeks before initiation of inebilizumab. Live vaccines should not be given to individuals who are considered to be immunocompromised until more information is available. The immunosuppressive effects of steroid treatment differ, but many clinicians consider a dose equivalent to either 2 mg/kg/day or 20 mg/day of prednisone as sufficiently immunosuppressive to raise concern about the safety of immunization with live vaccines. The immune response of the immunocompromised patient to vaccines may be decreased, even despite alternate vaccination schedules or more frequent booster doses. … Live vaccines should not be given to individuals who are considered to be immunocompromised until more information is available. Postpone instillation of BCG if the patient is receiving antibiotics. Postpone instillation of BCG if the patient is receiving antibiotics. Abatacept: (Severe) If possible, administer all needed vaccines before abatacept initiation. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune system. Administer all live or live-attenuated vaccinations according to current vaccination guidelines at least 4 weeks before initiation of ocrelizumab. Rituximab: (Severe) Do not administer live vaccines to rituximab recipients; no data are available regarding the risk of secondary transmission of infection by live vaccines in patients receiving rituximab. The immune response of the immunocompromised patient to vaccines may be decreased, even despite alternate vaccination schedules or more frequent booster doses. After usage, all equipment and materials used for preparation and administration of the BCG Vaccine should be placed into plastic bags labeled 'Infectious Waste' and disposed of accordingly as biohazardous waste. The CDC has stated that discontinuation of steroids for 1 month prior to live vaccine administration may be sufficient. Vaccination with BCG simulates natural infection with M. tuberculosis and results in a cell-mediated immune reaction and immunity against tuberculosis. Isoniazid, INH; Rifampin: (Major) Postpone instillation of BCG if the patient is receiving antibiotics, such as isoniazid. Live vaccines should not be given to individuals who are considered to be immunocompromised until more information is available. Discard the multiple puncture device in a biohazard sharps container.Allow vaccine to dry to the arm. Docetaxel: (Severe) Do not administer live vaccines to docetaxel recipients; no data are available regarding the risk of secondary transmission of infection by live vaccines in patients receiving docetaxel. The immune response of the immunocompromised patient to vaccines may be decreased, even despite alternate vaccination schedules or more frequent booster doses. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune system. Live virus vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. Sirolimus: (Severe) Do not administer live vaccines to sirolimus recipients; no data are available regarding the risk of secondary transmission of infection by live vaccines in patients receiving sirolimus. For example, as compared with the response of placebo recipients, the capacity to mount a skin delayed-type hypersensitivity reaction to Candida and to tetanus toxoid was decreased by approximately 30% among fingolimod 0.5 mg daily recipients. Alemtuzumab: (Severe) Do not administer live vaccines to alemtuzumab recipients; no data are available regarding the risk of secondary transmission of infection by live vaccines in patients receiving alemtuzumab. No data are available regarding the risk of secondary transmission of infection by live vaccines, and the efficacy and safety of live vaccines have not been established in patients receiving canakinumab. BCG Vaccine for percutaneous use, is an attenuated, live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of Mycobacterium bovis.1 The TICE® strain used in this BCG Vaccine preparation was developed at the University of Illinois from a strain originated at the Pasteur Institute.The medium in which the TICE® BCG organism is grown for preparation of the freeze-dried cake is composed of the following ingredients… The most common side effects include fever, headache and swollen glands. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune system. Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. The U.S. Department of Health and Human Services has established a Vaccine Adverse Event Reporting System (VAERS) to accept all reports of suspected adverse events after the administration of any vaccine. At least 2 weeks before initiation of cytarabine therapy, consider completion of all age appropriate vaccinations per current immunization guidelines. The immune response to vaccines or toxoids may be decreased, as canakinumab may interfere with normal immune response to new antigens. Infants who need re-vaccination should receive a full dose vaccination after 1 year of age. Position the patient's arm such that the deltoid muscle is parallel to the floor, presenting a flat surface for vaccine application.The vaccine dose is dropped from the syringe onto the skin. The BCG vaccine protects against tuberculosis, which is also known as TB. Alpha interferons: (Severe) Live virus vaccines should generally not be administered to an immunosuppressed patient, including those receiving Interferon therapy. Live vaccines may induce the illness they are intended to prevent and are generally contraindicated for use during immunosuppressive treatment. Read more about the prescription drug BCG VACCINE - INTRAVESICAL. All equipment, supplies, and receptacles in contact with these products should be disposed of as biohazards. Practitioners should refer to the most recent CDC guidelines regarding vaccination of patients who are receiving drugs that adversely affect the immune system. To receive email updates about this page, enter your email address: Centers for Disease Control and Prevention. If experienced, these tend to have a Severe expression. Of 1716 infant recipients of the TICE strain, 17 cases of tuberculosis occurred over 12—23 years after vaccination. Live virus vaccines should generally not be administered to an immunosuppressed patient.

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